FOB1/YDR110W Summary Help

FOB1 BASIC INFORMATION

Standard Name FOB1 1
Systematic Name YDR110W
Alias HRM1 2
Feature Type ORF, Verified
Description Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases (1, 2, 3, 4, 5)
Name Description FOrk Blocking less 1
GO Annotations All FOB1 GO evidence and references
    View Computational GO annotations for FOB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All FOB1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
Interactions FOB1 All interactions details and references
55 total interaction(s) for 41 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Two-hybrid: 13
Genetic Interactions
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
  • Synthetic Rescue: 5
Sequence Information
ChrIV:676100 to 677800 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1701 676100..677800 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002517

FOB1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for FOB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for FOB1]

1) Kobayashi T and Horiuchi T  (1996) A yeast gene product, Fob1 protein, required for both replication fork blocking and recombinational hotspot activities. Genes Cells 1(5):465-74
2) Defossez PA, et al.  (1999) Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol Cell 3(4):447-55
3) Dlakic M  (2002) A model of the replication fork blocking protein Fob1p based on the catalytic core domain of retroviral integrases. Protein Sci 11(5):1274-7
4) Kobayashi T  (2003) The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork. Mol Cell Biol 23(24):9178-88
5) Johzuka K and Horiuchi T  (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35