Standard Name	FOB1 1
Systematic Name	YDR110W
Alias	HRM1 2
Feature Type	ORF, Verified
Description	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases (1, 2, 3, 4, 5)
Name Description	FOrk Blocking less 1

Chromosomal Location	ChrIV:676102 to 677802 | ORF Map | GBrowse

Molecular Function
Manually curated	rDNA spacer replication fork barrier binding (IDA)
Biological Process
Manually curated	chromatin silencing at rDNA (IDA) DNA recombination (IMP) extrachromosomal circular DNA accumulation involved in cell aging (IMP) negative regulation of DNA replication (IDA) protein localization to nucleolar rDNA repeats (IMP) rDNA condensation (IMP) replicative cell aging (IMP)
Cellular Component
Manually curated	nucleolus (IDA) rDNA heterochromatin (IDA)

Classical genetics
null	lifespan: increased meiotic recombination: increased mitotic recombination: decreased replicative lifespan: increased resistance to methyl methanesulfonate: increased sporulation efficiency: increased
overexpression	sporulation efficiency: decreased
unspecified	mitotic recombination: decreased replicative lifespan: increased
Large-scale survey
null	competitive fitness: decreased haploinsufficient replicative lifespan: increased resistance to nickel sulfate: decreased starvation resistance: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	96 total interaction(s) for 61 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Reconstituted Complex: 2 Two-hybrid: 16
Genetic Interactions	Negative Genetic: 11 Phenotypic Enhancement: 10 Phenotypic Suppression: 11 Synthetic Growth Defect: 7 Synthetic Lethality: 5 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:676102 to 677802 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1701 676102..677802 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002517