ARX1/YDR101C Summary Help

Standard Name ARX1 1
Systematic Name YDR101C
Feature Type ORF, Verified
Description Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex (2, 3, 4, 5)
Name Description Associated with Ribosomal eXport complex 1
Chromosomal Location
ChrIV:657467 to 655686 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All ARX1 GO evidence and references
  View Computational GO annotations for ARX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
437 total interaction(s) for 148 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 177
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 106
  • Co-crystal Structure: 7
  • Co-purification: 5
  • PCA: 1
  • Reconstituted Complex: 15
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 59
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 8
  • Synthetic Growth Defect: 28
  • Synthetic Lethality: 12
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 593
Molecular Weight (Da) 65,212
Isoelectric Point (pI) 7.17
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:657467 to 655686 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1782 657467..655686 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002508
References cited on this page View Complete Literature Guide for ARX1
1) Nissan TA, et al.  (2002) 60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. EMBO J 21(20):5539-47
2) Hung NJ and Johnson AW  (2006) Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiae. Mol Cell Biol 26(10):3718-27
3) Lebreton A, et al.  (2006) A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. J Cell Biol 173(3):349-60
4) Hung NJ, et al.  (2008) Arx1 Is a Nuclear Export Receptor for the 60S Ribosomal Subunit in Yeast. Mol Biol Cell 19(2):735-44
5) Bradatsch B, et al.  (2007) Arx1 functions as an unorthodox nuclear export receptor for the 60S preribosomal subunit. Mol Cell 27(5):767-79