SLU7/YDR088C Summary Help

Standard Name SLU7 1
Systematic Name YDR088C
Alias SLT17 2
Feature Type ORF, Verified
Description RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain (3)
Name Description Synergistic Lethal with U5 snRNA 1
Chromosomal Location
ChrIV:619645 to 618497 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All SLU7 GO evidence and references
  View Computational GO annotations for SLU7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
conditional
Large-scale survey
null
reduction of function
Resources
130 total interaction(s) for 102 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-fractionation: 4
  • Reconstituted Complex: 1
  • Two-hybrid: 12

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 73
  • Positive Genetic: 8
  • Synthetic Lethality: 18
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 382
Molecular Weight (Da) 44,636
Isoelectric Point (pI) 9.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:619645 to 618497 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1149 619645..618497 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002495
References cited on this page View Complete Literature Guide for SLU7
1) Frank D, et al.  (1992) Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol 12(11):5197-205
2) Xu D, et al.  (1998) Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. Mol Cell Biol 18(4):2055-66
3) James SA, et al.  (2002) How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing. RNA 8(8):1068-77