Standard Name	RRG1 1
Systematic Name	YDR065W
Feature Type	ORF, Verified
Description	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies (1, 2, 3)
Name Description	Required for Respiratory Growth 1

Chromosomal Location	ChrIV:580687 to 581784 | ORF Map | GBrowse

	View Computational GO annotations for RRG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial genome maintenance (IMP) vacuolar acidification (IMP)
Cellular Component
High-throughput	mitochondrion (IDA)

Classical genetics
null	chronological lifespan: decreased mitochondrial genome maintenance: abnormal
Large-scale survey
null	UV resistance: decreased acid pH resistance: decreased cell size: decreased glycogen accumulation: decreased competitive fitness: decreased dessication resistance: decreased haploinsufficient heat sensitivity: increased meiosis: abnormal metal resistance: increased mitochondrial morphology: abnormal Fus-Mid-GFP distribution: abnormal resistance to ethanol: decreased resistance to 4-chlorophenol: decreased resistance to 2,4-dichlorophenol: decreased resistance to nickel sulfate: decreased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to hygromycin B: decreased respiratory growth: decreased rate respiratory growth: absent stress resistance: increased toxin resistance: increased utilization of carbon source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	21 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2
Genetic Interactions	Negative Genetic: 7 Positive Genetic: 4 Synthetic Growth Defect: 6 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:580687 to 581784 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1098 580687..581784 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002472