YOS9/YDR057W Summary Help

Standard Name YOS9 1
Systematic Name YDR057W
Feature Type ORF, Verified
Description ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family (2, 3, 4, 5, 6, 7, 8)
Name Description Yeast OS-9 homolog 1
Chromosomal Location
ChrIV:565927 to 567555 | ORF Map | GBrowse
Gene Ontology Annotations All YOS9 GO evidence and references
  View Computational GO annotations for YOS9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
89 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 14
  • Affinity Capture-Western: 16
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 13
  • Phenotypic Enhancement: 19
  • Phenotypic Suppression: 12
  • Positive Genetic: 9
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 542
Molecular Weight (Da) 61,257
Isoelectric Point (pI) 4.33
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:565927 to 567555 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1629 565927..567555 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002464
References cited on this page View Complete Literature Guide for YOS9
1) Friedmann E, et al.  (2002) YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J Biol Chem 277(38):35274-81
2) Buschhorn BA, et al.  (2004) A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins. FEBS Lett 577(3):422-6
3) Szathmary R, et al.  (2005) Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD. Mol Cell 19(6):765-75
4) Bhamidipati A, et al.  (2005) Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER Lumen. Mol Cell 19(6):741-51
5) Kim W, et al.  (2005) Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Mol Cell 19(6):753-64
6) Gauss R, et al.  (2006) A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery. Nat Cell Biol 8(8):849-54
7) Quan EM, et al.  (2008) Defining the glycan destruction signal for endoplasmic reticulum-associated degradation. Mol Cell 32(6):870-7
8) Izawa T, et al.  (2012) Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation. Mol Biol Cell 23(7):1283-93