Standard Name	YOS9 1
Systematic Name	YDR057W
Feature Type	ORF, Verified
Description	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family (2, 3, 4, 5, 6, 7)
Name Description	Yeast OS-9 homolog 1

Chromosomal Location	ChrIV:565927 to 567555 | ORF Map | GBrowse

	View Computational GO annotations for YOS9
Molecular Function
Manually curated	oligosaccharide binding (IDA)
Biological Process
Manually curated	ER-associated protein catabolic process (IMP)
Cellular Component
Manually curated	endoplasmic reticulum lumen (IDA) colocalizes_with Hrd1p ubiquitin ligase ERAD-L complex (IPI) luminal surveillance complex (IDA)

Classical genetics
null	CPY* accumulation: increased
Large-scale survey
null	anaerobic growth: decreased auxotrophy glycogen accumulation: increased competitive fitness: decreased resistance to streptomycin: decreased resistance to tirapazamine: increased resistance to clioquinol: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	86 total interaction(s) for 42 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 14 Co-crystal Structure: 1 Co-fractionation: 1 Reconstituted Complex: 2
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 12 Phenotypic Enhancement: 19 Phenotypic Suppression: 12 Positive Genetic: 9 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:565927 to 567555 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1629 565927..567555 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002464