VMS1/YDR049W Summary Help

Standard Name VMS1 1
Systematic Name YDR049W
Feature Type ORF, Verified
Description Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans (1, 2, 3)
Name Description VCP/Cdc48-associated Mitochondrial Stress-responsive 1
Chromosomal Location
ChrIV:553254 to 555152 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All VMS1 GO evidence and references
  View Computational GO annotations for VMS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 260 genes
Regulators 69 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
220 total interaction(s) for 179 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 13
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 150
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 1
  • Positive Genetic: 14
  • Synthetic Growth Defect: 11
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 632
Molecular Weight (Da) 72,733
Isoelectric Point (pI) 9.64
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:553254 to 555152 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1899 553254..555152 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002456
References cited on this page View Complete Literature Guide for VMS1
1) Heo JM, et al.  (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80
2) Bohm S, et al.  (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
3) Tran JR, et al.  (2011) A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis. J Biol Chem 286(7):5744-55