NRG1/YDR043C Summary Help

NRG1 BASIC INFORMATION

Standard Name NRG1 1
Systematic Name YDR043C
Feature Type ORF, Verified
Description Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response (1, 2, 3, 4)
Name Description Negative Regulator of Glucose-repressed genes 1, 2
GO Annotations All NRG1 GO evidence and references
    View Computational GO annotations for NRG1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Binding motifs NRG1 Transcription Factor Binding Sites and References
  • CCCT
  • GGACCCT
Regulatory modules predicted: cellcycle ( 389 )
Mutant Phenotype All NRG1 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions NRG1 All interactions details and references
24 total interaction(s) for 14 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 11
Sequence Information
ChrIV:543368 to 542673 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..696 543368..542673 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002450

NRG1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for NRG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NRG1]

1) Zhou H and Winston F  (2001) NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiae. BMC Genet 2():5
2) Park SH, et al.  (1999) Nrg1 is a transcriptional repressor for glucose repression of STA1 gene expression in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2044-50
3) Kuchin S, et al.  (2002) Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Mol Cell Biol 22(12):3994-4000
4) Lamb TM and Mitchell AP  (2003) The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae. Mol Cell Biol 23(2):677-86