SUMMARY PARAGRAPH for ENA5
ENA5 is the last member of a tandem array of genes encoding nearly, but not perfectly, identical P-Type ATPases. The reference strain, S288c, contains three genes in this cluster: ENA1, ENA2, and ENA5. Other Saccharomyces strains typically contain 4 or 5 genes (ENA1-ENA5) (1, 3).
ENA1 is the most well characterized member of this cluster and is thought to encode the primary plasma membrane Na+-ATPase exporter in S. cerevisiae. Ena1p plays a critical role in the detoxification of Na+ ions and in maintaining ion homeostasis, making Ena1p a principal component of the cell's ability to survive high salt or alkaline conditions (4). Ena1p and Ena2p both transport Li+ ions, but with differing efficiencies (1), and have been shown to export K+ ions concomitantly with Na+, at some salt concentrations (5).
Ena1p-Ena5p are closely related to Pmr1p (1), the Golgi membrane Ca2+-ATPase. Mutations in the human homolog of Pmr1p, ATP2C1, cause the acantholytic skin condition Hailey-Hailey disease (6).
Last updated: 2006-10-31