ARO3/YDR035W Summary Help

Standard Name ARO3
Systematic Name YDR035W
Feature Type ORF, Verified
Description 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan (1, 2, 3)
Name Description AROmatic amino acid requiring
Chromosomal Location
ChrIV:521816 to 522928 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ARO3 GO evidence and references
  View Computational GO annotations for ARO3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Pathways
Large-scale survey
null
Resources
22 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 8
  • Positive Genetic: 1
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 370
Molecular Weight (Da) 41,070
Isoelectric Point (pI) 7.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:521816 to 522928 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1113 521816..522928 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002442
References cited on this page View Complete Literature Guide for ARO3
1) Paravicini G, et al.  (1988) Structure of the ARO3 gene of Saccharomyces cerevisiae. Mol Gen Genet 214(1):165-9
2) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
3) Helmstaedt K, et al.  (2005) Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 102(28):9784-9