LYS14/YDR034C Summary Help

Standard Name LYS14 1
Systematic Name YDR034C
Feature Type ORF, Verified
Description Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer (2, 3, 4, 5)
Name Description LYSine requiring
Chromosomal Location
ChrIV:512109 to 509737 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 8 cM
Gene Ontology Annotations All LYS14 GO evidence and references
  View Computational GO annotations for LYS14
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
reduction of function
Large-scale survey
19 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 11
  • Synthetic Growth Defect: 2

Expression Summary
Length (a.a.) 790
Molecular Weight (Da) 89,396
Isoelectric Point (pI) 6.92
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:512109 to 509737 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: 8 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2373 512109..509737 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002441
References cited on this page View Complete Literature Guide for LYS14
1) Contopoulou, C.R.  (1989) Personal Communication, Mortimer Map Edition 10
2) Becker B, et al.  (1998) A nonameric core sequence is required upstream of the LYS genes of Saccharomyces cerevisiae for Lys14p-mediated activation and apparent repression by lysine. Mol Microbiol 29(1):151-63
3) Feller A, et al.  (1994) Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation. Mol Cell Biol 14(10):6411-8
4) Ramos F, et al.  (1988) Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14. Eur J Biochem 171(1-2):171-6
5) Alami ME, et al.  (2002) The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector. Mol Microbiol 43(6):1629-39
6) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
7) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87