Standard Name	RAD61 1
Systematic Name	YDR014W
Alias	WPL1 2
Feature Type	ORF, Verified
Description	Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin (2, 3, 4, 5, 6)
Name Description	RADiation sensitive 1

Chromosomal Location	ChrIV:474046 to 475989 | ORF Map | GBrowse

	View Computational GO annotations for RAD61
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitotic sister chromatid cohesion (IGI) negative regulation of cohesin localization to chromatin (IMP) negative regulation of maintenance of mitotic sister chromatid cohesion (IMP) regulation of chromosome condensation (IMP)
Cellular Component
Manually curated	colocalizes_with nuclear cohesin complex (IDA)

Classical genetics
null	X ray resistance: decreased cell shape: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased gamma ray resistance: decreased Mcd1p accumulation: decreased vegetative growth: decreased viable
Large-scale survey
null	polyphosphate accumulation: abnormal colony sectoring: increased competitive fitness: decreased gamma ray resistance: decreased haploproficient oxidative stress resistance: decreased resistance to sodium selenide: decreased resistance to tunicamycin: decreased resistance to methyl methanesulfonate: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to camptothecin: decreased viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	162 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 3 Dosage Rescue: 1 Negative Genetic: 95 Phenotypic Enhancement: 4 Phenotypic Suppression: 6 Positive Genetic: 11 Synthetic Growth Defect: 19 Synthetic Lethality: 8 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:474046 to 475989 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1944 474046..475989 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002421