Standard Name	YRB1 1
Systematic Name	YDR002W
Alias	CST20 2 , HTN1 3 , SFO1
Feature Type	ORF, Verified
Description	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 (1, 2, 4, 5, 6, 7)
Name Description	Yeast Ran Binder 1

Chromosomal Location	ChrIV:453045 to 453650 | ORF Map | GBrowse

	View Computational GO annotations for YRB1
Molecular Function
Manually curated	Ran GTPase binding (IDA)
Biological Process
Manually curated	G1/S transition of mitotic cell cycle (IMP) protein import into nucleus (IMP) RNA export from nucleus (IMP) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Classical genetics
conditional	nuclear export: abnormal nuclear import: decreased
null	inviable
overexpression	colony sectoring: increased mitotic recombination: increased resistance to hydroxyurea: decreased resistance to benomyl: decreased
Large-scale survey
null	haploproficient inviable resistance to sulfanilamide: decreased
overexpression	cell cycle progression: abnormal colony sectoring: increased vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	88 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 4 Affinity Capture-Western: 8 Biochemical Activity: 2 Reconstituted Complex: 6 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 36 Positive Genetic: 4 Synthetic Growth Defect: 2 Synthetic Lethality: 8 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:453045 to 453650 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..606 453045..453650 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002409