YRB1/YDR002W Summary Help

YRB1 BASIC INFORMATION

Standard Name YRB1 1
Systematic Name YDR002W
Alias CST20 2 , HTN1 3 , SFO1
Feature Type ORF, Verified
Description Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 (1, 2, 4, 5, 6, 7)
Name Description Yeast Ran Binder 1
GO Annotations All YRB1 GO evidence and references
    View Computational GO annotations for YRB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All YRB1 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions YRB1 All interactions details and references
37 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Biochemical Activity: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3
Sequence Information
ChrIV:453043 to 453648 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..606 453043..453648 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002409

YRB1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for YRB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YRB1]

1) Dingwall C, et al.  (1995) A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci U S A 92(16):7525-9
2) Ouspenski II, et al.  (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem 270(5):1975-8
3) Butler G and Wolfe KH  (1994) Yeast homologue of mammalian Ran binding protein 1. Biochim Biophys Acta 1219(3):711-2
4) Kunzler M, et al.  (2000) Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol 20(12):4295-308
5) Schlenstedt G, et al.  (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78
6) Baumer M, et al.  (2000) Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem 275(49):38929-37
7) Kunzler M, et al.  (2001) Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics 157(3):1089-105