YRB1/YDR002W Summary Help

Standard Name YRB1 1
Systematic Name YDR002W
Alias CST20 2 , HTN1 3 , SFO1 , STP52 4
Feature Type ORF, Verified
Description Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 (1, 2, 4, 5, 6, 7)
Name Description Yeast Ran Binder 1
Chromosomal Location
ChrIV:453045 to 453650 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YRB1 GO evidence and references
  View Computational GO annotations for YRB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 9 genes
Resources
Classical genetics
conditional
null
overexpression
Large-scale survey
null
overexpression
reduction of function
Resources
93 total interaction(s) for 67 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Affinity Capture-RNA: 6
  • Affinity Capture-Western: 8
  • Biochemical Activity: 2
  • Reconstituted Complex: 6
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 38
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 8
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 201
Molecular Weight (Da) 22,953
Isoelectric Point (pI) 5.96
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:453045 to 453650 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..606 453045..453650 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002409
References cited on this page View Complete Literature Guide for YRB1
1) Dingwall C, et al.  (1995) A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci U S A 92(16):7525-9
2) Ouspenski II, et al.  (1995) Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem 270(5):1975-8
3) Butler G and Wolfe KH  (1994) Yeast homologue of mammalian Ran binding protein 1. Biochim Biophys Acta 1219(3):711-2
4) Kunzler M, et al.  (2001) Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Genetics 157(3):1089-105
5) Kunzler M, et al.  (2000) Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Mol Cell Biol 20(12):4295-308
6) Schlenstedt G, et al.  (1995) Mutants in a yeast Ran binding protein are defective in nuclear transport. EMBO J 14(21):5367-78
7) Baumer M, et al.  (2000) Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. J Biol Chem 275(49):38929-37