LRG1/YDL240W Summary

LRG1 BASIC INFORMATION

Standard Name	LRG1
Systematic Name	YDL240W
Feature Type	ORF, Verified
Description	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis (1)
Name Description	Lim-RhoGap homolog 2

GO Annotations	All LRG1 GO evidence and references
	View Computational GO annotations for LRG1
Molecular Function
Manually curated	Rho GTPase activator activity (IDA)
Biological Process
Manually curated	fungal-type cell wall biogenesis (IGI) small GTPase mediated signal transduction (IC, IPI)
Cellular Component
High-throughput	cellular bud neck (IDA) cytoplasm (IDA) mitochondrion (IDA)

Mutant Phenotype	All LRG1 Phenotype details and references
Classical genetics
null	invasive growth: increased mating efficiency: decreased viable
Large-scale survey
null	viable
overexpression	resistance to rapamycin: decreased

Interactions	LRG1 All interactions details and references
	29 total interaction(s) for 20 unique genes/features.
Physical Interactions	Biochemical Activity: 1 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 3 Phenotypic Enhancement: 5 Synthetic Rescue: 11

Sequence Information

ChrIV:22823 to 25876 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3054	22823..25876	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002399

LRG1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for LRG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LRG1]

1)	Lorberg A, et al. (2001) Lrg1p functions as a putative GTPase-activating protein in the Pkc1p-mediated cell integrity pathway in Saccharomyces cerevisiae. Mol Genet Genomics 266(3):514-26
2)	Muller L, et al. (1994) LRG1 is expressed during sporulation in Saccharomyces cerevisiae and contains motifs similar to LIM and rho/racGAP domains. Nucleic Acids Res 22(15):3151-4

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