Standard Name	PTP1
Systematic Name	YDL230W
Feature Type	ORF, Verified
Description	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation (1, 2, 3)
Name Description	Protein Tyrosine Phosphatase

Chromosomal Location	ChrIV:42700 to 43707 | ORF Map | GBrowse

	View Computational GO annotations for PTP1
Molecular Function
Manually curated	protein tyrosine phosphatase activity (IDA, ISS)
Biological Process
Manually curated	invasive growth in response to glucose limitation (IMP) protein dephosphorylation (IDA, IMP) pseudohyphal growth (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) mitochondrion (IDA)

Regulatory modules	predicted: cellcycle (377, 305)

Classical genetics
overexpression	invasive growth: decreased pseudohyphal growth: decreased
Large-scale survey
null	competitive fitness: decreased resistance to camptothecin: increased resistance to bleomycin: increased resistance to amitrole: decreased resistance to cycloheximide: increased resistance to caffeine: increased resistance to fluconazole: increased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	75 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 1 Biochemical Activity: 4 Protein-peptide: 5 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 52 Positive Genetic: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:42700 to 43707 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1008 42700..43707 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002389