RRI1/YDL216C Summary

RRI1 BASIC INFORMATION

Standard Name	RRI1 1
Systematic Name	YDL216C
Alias	CSN5 , JAB1
Feature Type	ORF, Verified
Description	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling (2, 3, 4)
Name Description	Regulator of Rub1 specific Isopeptidase

GO Annotations	All RRI1 GO evidence and references
	View Computational GO annotations for RRI1
Molecular Function
Manually curated	metalloendopeptidase activity (IMP)
Biological Process
Manually curated	adaptation to pheromone during conjugation with cellular fusion (IMP) cullin deneddylation (IMP)
Cellular Component
Manually curated	signalosome (IDA)

Mutant Phenotype	All RRI1 Phenotype details and references
Classical genetics
null	mating efficiency: increased Cdc53p modification: increased Lag2p modification: decreased recovery from pheromone-induced cell cycle arrest: decreased shmoo formation: increased rate
Large-scale survey
null	viable

Interactions	RRI1 All interactions details and references
	34 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 1 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 5 Phenotypic Suppression: 1

Sequence Information

ChrIV:70320 to 68998 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-04-13 | Sequence: 2006-04-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1323	70320..68998	2006-04-13	2006-04-13

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002375

RRI1 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RRI1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RRI1]

1)	Lyapina S, et al. (2001) Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292(5520):1382-5
2)	Cope GA, et al. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298(5593):608-11
3)	Wee S, et al. (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15
4)	Maytal-Kivity V, et al. (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21

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