NOP6/YDL213C Summary Help

Standard Name NOP6 1
Systematic Name YDL213C
Feature Type ORF, Verified
Description rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes (2, 3, 4, 5)
Name Description NucleOlar Protein 1
Chromosomal Location
ChrIV:77966 to 77289 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All NOP6 GO evidence and references
  View Computational GO annotations for NOP6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
130 total interaction(s) for 105 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 92
  • Affinity Capture-RNA: 2
  • PCA: 5
  • Reconstituted Complex: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 17
  • Positive Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 225
Molecular Weight (Da) 25,216
Isoelectric Point (pI) 10.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:77966 to 77289 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..678 77966..77289 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002372
References cited on this page View Complete Literature Guide for NOP6
1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Garay-Arroyo A, et al.  (2000) Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit. J Biol Chem 275(8):5668-74
3) Buchhaupt M, et al.  (2007) Mutations in the nucleolar proteins Tma23 and Nop6 suppress the malfunction of the Nep1 protein. FEMS Yeast Res 7(6):771-81
4) Garcia-Gomez JJ, et al.  (2011) Nop6, a component of 90S pre-ribosomal particles, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae. RNA Biol 8(1):112-24
5) Lopez-Martinez G, et al.  (2012) The STF2p Hydrophilin from Saccharomyces cerevisiae Is Required for Dehydration Stress Tolerance. PLoS One 7(3):e33324