SHR3/YDL212W Summary Help

Standard Name SHR3 1
Systematic Name YDL212W
Alias APF1 2
Feature Type ORF, Verified
Description Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface (1, 3, 4)
Name Description Super high Histidine Resistant 1
Chromosomal Location
ChrIV:78426 to 79058 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SHR3 GO evidence and references
  View Computational GO annotations for SHR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
reduction of function
unspecified
Large-scale survey
null
reduction of function
Resources
322 total interaction(s) for 254 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 5
  • Biochemical Activity: 1
  • Co-localization: 1
  • PCA: 64
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 155
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 4
  • Positive Genetic: 51
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 210
Molecular Weight (Da) 23,512
Isoelectric Point (pI) 8.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:78426 to 79058 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..633 78426..79058 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002371
References cited on this page View Complete Literature Guide for SHR3
1) Ljungdahl PO, et al.  (1992) SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases in yeast. Cell 71(3):463-78
2) Grenson M and Hennaut C  (1971) Mutation affecting activity of several distinct amino acid transport systems in Saccharomyces cerevisiae. J Bacteriol 105(2):477-82
3) Gilstring CF, et al.  (1999) Shr3p mediates specific COPII coatomer-cargo interactions required for the packaging of amino acid permeases into ER-derived transport vesicles. Mol Biol Cell 10(11):3549-65
4) Kuehn MJ, et al.  (1996) Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. J Cell Biol 135(3):585-95