NHP2/YDL208W Summary

NHP2 BASIC INFORMATION

Standard Name	NHP2 1
Systematic Name	YDL208W
Feature Type	ORF, Verified
Description	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing (1, 2)
Name Description	Non-Histone Protein 1

GO Annotations	All NHP2 GO evidence and references
	View Computational GO annotations for NHP2
Molecular Function
Manually curated	snoRNA binding (IDA)
Biological Process
Manually curated	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) rRNA pseudouridine synthesis (IMP) snRNA pseudouridine synthesis (IDA, IMP)
Cellular Component
Manually curated	small nucleolar ribonucleoprotein complex (IPI)

Mutant Phenotype	All NHP2 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	NHP2 All interactions details and references
	77 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 47 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Co-purification: 1 PCA: 8 Reconstituted Complex: 5 Two-hybrid: 5
Genetic Interactions	Synthetic Growth Defect: 2

Sequence Information

ChrIV:87513 to 87983 | |

Last Update

Coordinates: 2005-11-22 | Sequence: 2005-11-22

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..471	87513..87983	2005-11-22	2005-11-22

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002367

NHP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NHP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NHP2]

1)	Kolodrubetz D and Burgum A (1991) Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. Yeast 7(2):79-90
2)	Henras A, et al. (1998) Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. EMBO J 17(23):7078-90

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