UFD2/YDL190C Summary Help

Standard Name UFD2 1
Systematic Name YDL190C
Feature Type ORF, Verified
Description Ubiquitin chain assembly factor (E4); cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 (2, 3)
Name Description Ubiquitin Fusion Degradation 1
Chromosomal Location
ChrIV:121592 to 118707 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All UFD2 GO evidence and references
  View Computational GO annotations for UFD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Classical genetics
null
Large-scale survey
null
overexpression
Resources
182 total interaction(s) for 92 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 25
  • Biochemical Activity: 1
  • Co-purification: 7
  • Protein-peptide: 1
  • Reconstituted Complex: 8
  • Two-hybrid: 18

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 1
  • Negative Genetic: 46
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 14
  • Positive Genetic: 9
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 3
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 961
Molecular Weight (Da) 109,915
Isoelectric Point (pI) 5.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:121592 to 118707 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2886 121592..118707 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002349
References cited on this page View Complete Literature Guide for UFD2
1) Johnson ES, et al.  (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem 270(29):17442-56
2) Koegl M, et al.  (1999) A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96(5):635-44
3) Hatakeyama S and Nakayama KI  (2003) U-box proteins as a new family of ubiquitin ligases. Biochem Biophys Res Commun 302(4):635-45