Standard Name	PPH22 1
Systematic Name	YDL188C
Alias	PPH2
Feature Type	ORF, Verified
Description	Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	Protein PHosphatase 1

Chromosomal Location	ChrIV:124998 to 123865 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -102 cM

	View Computational GO annotations for PPH22
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	actin filament organization (TAS) budding cell bud growth (TAS) G1/S transition of mitotic cell cycle (IGI) mitotic spindle assembly checkpoint (IPI) protein dephosphorylation (IDA) regulation of translation (IPI)
Cellular Component
Manually curated	condensed nuclear chromosome, centromeric region (IDA)

Classical genetics
null	prion formation: increased viability: increased
overexpression	budding index: abnormal cell cycle progression in G1 phase: abnormal cell size: increased cellular morphology: abnormal
Large-scale survey
null	haploproficient resistance to benzo[a]pyrene: increased resistance to cycloheximide: decreased resistance to cycloheximide: increased resistance to hydroxyurea: increased resistance to fenpropimorph: decreased resistance to methyl methanesulfonate: decreased resistance to camptothecin: increased resistance to benzo[a]pyrene: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
unspecified	resistance to Calcofluor White: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	155 total interaction(s) for 94 unique genes/features.
Physical Interactions	Affinity Capture-MS: 66 Affinity Capture-RNA: 1 Affinity Capture-Western: 12 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 4 Dosage Rescue: 6 Negative Genetic: 19 Phenotypic Enhancement: 6 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 8 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 10 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:124998 to 123865 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: -102 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1134 124998..123865 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002347