INH1/YDL181W Summary Help

Standard Name INH1 1
Systematic Name YDL181W
Feature Type ORF, Verified
Description Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication (2, 3, 4)
Name Description INHibitor (of F1F0-ATPase) 1
Chromosomal Location
ChrIV:135179 to 135436 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All INH1 GO evidence and references
  View Computational GO annotations for INH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
65 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 3
  • Co-purification: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 9

Genetic Interactions
  • Negative Genetic: 32
  • Positive Genetic: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 85
Molecular Weight (Da) 9,870
Isoelectric Point (pI) 10.86
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:135179 to 135436 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..258 135179..135436 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002340
References cited on this page View Complete Literature Guide for INH1
1) Ichikawa N, et al.  (1990) Activation of ATP hydrolysis by an uncoupler in mutant mitochondria lacking an intrinsic ATPase inhibitor in yeast. J Biol Chem 265(11):6274-8
2) Dienhart M, et al.  (2002) Formation of the yeast F1F0-ATP synthase dimeric complex does not require the ATPase inhibitor protein, Inh1. J Biol Chem 277(42):39289-95
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Contessi S, et al.  (2005) Identification of a conserved calmodulin-binding motif in the sequence of F0F1 ATPsynthase inhibitor protein. J Bioenerg Biomembr 37(5):317-26