UGA3/YDL170W Summary Help

Standard Name UGA3 1, 2
Systematic Name YDL170W
Feature Type ORF, Verified
Description Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4 (3, 4, 5, 6)
Name Description Utilization of GAba 2
Chromosomal Location
ChrIV:156318 to 157904 | ORF Map | GBrowse
Gene Ontology Annotations All UGA3 GO evidence and references
  View Computational GO annotations for UGA3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 433 genes
Regulators 6 genes
Classical genetics
reduction of function
Large-scale survey
23 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Co-localization: 1

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 6

Expression Summary
Length (a.a.) 528
Molecular Weight (Da) 61,223
Isoelectric Point (pI) 6.68
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:156318 to 157904 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1587 156318..157904 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002329
References cited on this page View Complete Literature Guide for UGA3
1) Andre B  (1990) The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. Mol Gen Genet 220(2):269-76
2) Ramos F, et al.  (1985) Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem 149(2):401-4
3) Talibi D, et al.  (1995) Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae. Nucleic Acids Res 23(4):550-7
4) Noel J and Turcotte B  (1998) Zinc cluster proteins Leu3p and Uga3p recognize highly related but distinct DNA targets. J Biol Chem 273(28):17463-8
5) Idicula AM, et al.  (2002) Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. J Biol Chem 277(48):45977-83
6) Sylvain MA, et al.  (2011) Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of ?-aminobutyrate responsive genes. Genetics 188(3):523-34
7) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87