UGA3/YDL170W Summary Help

Standard Name UGA3 1, 2
Systematic Name YDL170W
Feature Type ORF, Verified
Description Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4 (3, 4, 5, 6)
Name Description Utilization of GAba 2
Chromosomal Location
ChrIV:156318 to 157904 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All UGA3 GO evidence and references
  View Computational GO annotations for UGA3
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 433 genes
Regulators 6 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Resources
23 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Co-localization: 1

Genetic Interactions
  • Negative Genetic: 11
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 528
Molecular Weight (Da) 61,223
Isoelectric Point (pI) 6.68
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:156318 to 157904 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1587 156318..157904 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002329
References cited on this page View Complete Literature Guide for UGA3
1) Andre B  (1990) The UGA3 gene regulating the GABA catabolic pathway in Saccharomyces cerevisiae codes for a putative zinc-finger protein acting on RNA amount. Mol Gen Genet 220(2):269-76
2) Ramos F, et al.  (1985) Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem 149(2):401-4
3) Talibi D, et al.  (1995) Cis- and trans-acting elements determining induction of the genes of the gamma-aminobutyrate (GABA) utilization pathway in Saccharomyces cerevisiae. Nucleic Acids Res 23(4):550-7
4) Noel J and Turcotte B  (1998) Zinc cluster proteins Leu3p and Uga3p recognize highly related but distinct DNA targets. J Biol Chem 273(28):17463-8
5) Idicula AM, et al.  (2002) Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. J Biol Chem 277(48):45977-83
6) Sylvain MA, et al.  (2011) Yeast zinc cluster proteins Dal81 and Uga3 cooperate by targeting common coactivators for transcriptional activation of ?-aminobutyrate responsive genes. Genetics 188(3):523-34
7) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87