FAP7/YDL166C Summary Help

Standard Name FAP7 1
Systematic Name YDL166C
Feature Type ORF, Verified
Description Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes (2, 3)
Name Description Factor Activating Pos9 1
Chromosomal Location
ChrIV:164042 to 163449 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All FAP7 GO evidence and references
  View Computational GO annotations for FAP7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
Resources
48 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 6
  • PCA: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 197
Molecular Weight (Da) 22,723
Isoelectric Point (pI) 4.35
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:164042 to 163449 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..594 164042..163449 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002325
References cited on this page View Complete Literature Guide for FAP7
1) Juhnke H, et al.  (2000) The essential protein fap7 is involved in the oxidative stress response of Saccharomyces cerevisiae. Mol Microbiol 35(4):936-48
2) Granneman S, et al.  (2005) The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14. Mol Cell Biol 25(23):10352-64
3) Strunk BS, et al.  (2012) A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits. Cell 150(1):111-21