Standard Name	ENT1 1
Systematic Name	YDL161W
Feature Type	ORF, Verified
Description	Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication (1, 2, 3)
Name Description	Epsin N-Terminal homology 1

Chromosomal Location	ChrIV:167714 to 169078 | ORF Map | GBrowse

	View Computational GO annotations for ENT1
Molecular Function
Manually curated	clathrin binding (TAS)
Biological Process
Manually curated	actin cortical patch assembly (IMP) actin filament organization (IMP) endocytosis (IMP)
Cellular Component
Manually curated	actin cortical patch (TAS)
High-throughput	cellular bud neck (IDA) cellular bud tip (IDA) cytoplasm (IDA) mating projection tip (IDA)

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: increased endocytosis: decreased haploinsufficient resistance to benzo[a]pyrene: decreased viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	48 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 8 Co-localization: 1 Reconstituted Complex: 3 Two-hybrid: 10
Genetic Interactions	Dosage Rescue: 3 Negative Genetic: 8 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:167714 to 169078 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1365 167714..169078 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002320