CMR1/YDL156W Summary Help

Standard Name CMR1 1, 2
Systematic Name YDL156W
Feature Type ORF, Verified
Description DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS (2, 3, 4, 5, 6)
Name Description Changed Mutation Rate 1
Chromosomal Location
ChrIV:174918 to 176486 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CMR1 GO evidence and references
  View Computational GO annotations for CMR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
overexpression
Resources
393 total interaction(s) for 329 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 279
  • Biochemical Activity: 1
  • Co-fractionation: 36
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 9
  • Synthetic Growth Defect: 65
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 522
Molecular Weight (Da) 59,155
Isoelectric Point (pI) 7.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:174918 to 176486 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1569 174918..176486 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002315
References cited on this page View Complete Literature Guide for CMR1
1) Offman J  (2008) personal communication
2) Choi DH, et al.  (2012) Saccharomyces cerevisiae Cmr1 protein preferentially binds to UV-damaged DNA in vitro. J Microbiol 50(1):112-8
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Hellauer K, et al.  (2005) Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae. Mol Pharmacol 68(5):1365-75
5) Brohee S, et al.  (2011) Unraveling networks of co-regulated genes on the sole basis of genome sequences. Nucleic Acids Res 39(15):6340-58
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76