MSH5/YDL154W Summary Help

MSH5 BASIC INFORMATION

Standard Name MSH5 1
Systematic Name YDL154W
Feature Type ORF, Verified
Description Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans (2, 3, 4)
Name Description MutS Homolog 1
GO Annotations All MSH5 GO evidence and references
    View Computational GO annotations for MSH5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All MSH5 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Interactions MSH5 All interactions details and references
22 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 1
  • Two-hybrid: 9
Genetic Interactions
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 3
  • Synthetic Lethality: 2
Sequence Information
ChrIV:178335 to 181040 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2706 178335..181040 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002313

MSH5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MSH5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSH5]

1) Hollingsworth NM, et al.  (1995) MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair. Genes Dev 9(14):1728-39
2) Winand NJ, et al.  (1998) Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene. Genomics 53(1):69-80
3) Pochart P, et al.  (1997) Conserved properties between functionally distinct MutS homologs in yeast. J Biol Chem 272(48):30345-9
4) Bawa S and Xiao W  (2003) A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Gene 315:177-82