RPN5/YDL147W Summary

RPN5 BASIC INFORMATION

Standard Name	RPN5 1
Systematic Name	YDL147W
Alias	NAS5
Feature Type	ORF, Verified
Description	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p (2, 3)
Name Description	Regulatory Particle Non-ATPase 1

GO Annotations	All RPN5 GO evidence and references
	View Computational GO annotations for RPN5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ubiquitin-dependent protein catabolic process (TAS)
Cellular Component
Manually curated	proteasome regulatory particle, lid subcomplex (IDA, IPI) proteasome storage granule (IDA)

Mutant Phenotype	All RPN5 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased

Interactions	RPN5 All interactions details and references
	247 total interaction(s) for 81 unique genes/features.
Physical Interactions	Affinity Capture-MS: 164 Affinity Capture-RNA: 1 Affinity Capture-Western: 17 Co-purification: 3 PCA: 3 Two-hybrid: 14
Genetic Interactions	Synthetic Growth Defect: 29 Synthetic Rescue: 16

Sequence Information

ChrIV:190925 to 192262 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1338	190925..192262	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002306

RPN5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPN5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN5]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Saito A, et al. (1997) cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. Gene 203(2):241-50
3)	Glickman MH, et al. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol 18(6):3149-62

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