Standard Name	COP1 (see Nomenclature conflict Note)
Systematic Name	YDL145C
Alias	SEC33 , RET1 , SOO1 1
Feature Type	ORF, Verified
Description	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway (2)
Name Description	COat Protein

Chromosomal Location	ChrIV:198176 to 194571 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for COP1
Molecular Function
Manually curated	ubiquitin binding (IDA)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) retrograde vesicle-mediated transport, Golgi to ER (IMP)
Cellular Component
Manually curated	COPI vesicle coat (IMP, ISS)

Classical genetics
conditional	carboxypeptidase Y secretion: abnormal
repressible	Pmp2GFP-KKTN distribution: decreased peroxisomal protein distribution: abnormal Pmp2GFP-LRKR distribution: decreased
Large-scale survey
null	inviable resistance to clioquinol: decreased
overexpression	vegetative growth: decreased
repressible	chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	237 total interaction(s) for 161 unique genes/features.
Physical Interactions	Affinity Capture-MS: 96 Affinity Capture-RNA: 2 Affinity Capture-Western: 13 Co-crystal Structure: 1 Protein-peptide: 1 Reconstituted Complex: 3 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 2 Dosage Rescue: 4 Negative Genetic: 84 Phenotypic Suppression: 1 Positive Genetic: 8 Synthetic Growth Defect: 6 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:198176 to 194571 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3606 198176..194571 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002304