RGT2/YDL138W Summary

RGT2 BASIC INFORMATION

Standard Name	RGT2 1
Systematic Name	YDL138W
Feature Type	ORF, Verified
Description	Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p (1, 2)
Name Description	Restores Glucose Transport 3

GO Annotations	All RGT2 GO evidence and references
	View Computational GO annotations for RGT2
Molecular Function
Manually curated	glucose binding (TAS) NOT glucose transmembrane transporter activity (TAS) receptor activity (TAS)
Biological Process
Manually curated	detection of glucose (IMP) NOT glucose transport (IGI) signal transduction (TAS)
Cellular Component
Manually curated	plasma membrane (IMP, ISS)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 383 , 365 )

Mutant Phenotype	All RGT2 Phenotype details and references
Classical genetics
activation	Mth1p accumulation: decreased Std1p accumulation: decreased Mth1p modification: increased Std1p modification: increased
Large-scale survey
null	viable
overexpression	filamentous growth: decreased invasive growth: absent

Interactions	RGT2 All interactions details and references
	14 total interaction(s) for 7 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 4 Synthetic Rescue: 5

Sequence Information

ChrIV:213352 to 215643 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2292	213352..215643	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000002297

RGT2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RGT2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RGT2]

1)	Ozcan S, et al. (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc Natl Acad Sci U S A 93(22):12428-32
2)	Ozcan S, et al. (1998) Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. EMBO J 17(9):2566-73
3)	Marshall-Carlson L, et al. (1991) Dominant and recessive suppressors that restore glucose transport in a yeast snf3 mutant. Genetics 128(3):505-12

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