Standard Name	SRF1 1 (see Nomenclature conflict Note)
Systematic Name	YDL133W
Feature Type	ORF, Verified
Description	Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients (1, 2)
Name Description	Spo14 Regulatory Factor 1

Chromosomal Location	ChrIV:222427 to 223740 | ORF Map | GBrowse

	View Computational GO annotations for SRF1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	positive regulation of catalytic activity (IMP)
Cellular Component
High-throughput	integral to membrane (ISM)

Classical genetics
null	calcium(2+) accumulation: decreased resistance to 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine: decreased
Large-scale survey
null	glycogen accumulation: increased competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to hygromycin B: decreased resistance to benzo[a]pyrene: increased resistance to lovastatin: decreased respiratory growth: absent stress resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	127 total interaction(s) for 110 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 3 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 101 Phenotypic Enhancement: 10 Positive Genetic: 9 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:222427 to 223740 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1314 222427..223740 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002291