SRF1/YDL133W Summary Help

Standard Name SRF1 1
Systematic Name YDL133W
Feature Type ORF, Verified
Description Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients (1, 2)
Name Description Spo14 Regulatory Factor 1
Chromosomal Location
ChrIV:222427 to 223740 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SRF1 GO evidence and references
  View Computational GO annotations for SRF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
136 total interaction(s) for 118 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 109
  • Phenotypic Enhancement: 10
  • Positive Genetic: 9
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 437
Molecular Weight (Da) 49,580
Isoelectric Point (pI) 9.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:222427 to 223740 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1314 222427..223740 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002291
References cited on this page View Complete Literature Guide for SRF1
1) Kennedy MA, et al.  (2011) Srf1 is a novel regulator of phospholipase d activity and is essential to buffer the toxic effects of c16:0 platelet activating factor. PLoS Genet 7(2):e1001299
2) Fisk DG, et al.  (2006) Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Yeast 23(12):857-65