HNT1/YDL125C Summary Help

HNT1 BASIC INFORMATION

Standard Name HNT1
Systematic Name YDL125C
Feature Type ORF, Verified
Description Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint (1, 2, 3, 4)
Name Description Histidine triad NucleoTide-binding
GO Annotations All HNT1 GO evidence and references
    View Computational GO annotations for HNT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All HNT1 Phenotype details and references
Large-scale survey
null
Interactions HNT1 All interactions details and references
16 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2
  • PCA: 1
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Lethality: 1
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
Sequence Information
ChrIV:239606 to 239019 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..97 239606..239510 2004-02-11 1996-07-31
Intron 98..208 239509..239399 2004-02-11 1996-07-31
CDS 209..588 239398..239019 2004-02-11 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002283

HNT1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for HNT1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
HIT1Nomenclature conflictThe name HIT1 has been used to describe both HNT1/YDL125C, a member of the histidine triad (HIT) superfamily, and HIT1/YJR055W, a gene required for high temperature growth.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HNT1]

1) Seraphin B  (1992) The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals. DNA Seq 3(3):177-9
2) Brenner C, et al.  (1997) Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Nat Struct Biol 4(3):231-8
3) Korsisaari N and Makela TP  (2000) Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins. J Biol Chem 275(45):34837-40
4) Bieganowski P, et al.  (2002) Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. J Biol Chem 277(13):10852-60