YDL124W Summary Help

Systematic Name YDL124W
Feature Type ORF, Verified
Description NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress (1, 2, 3)
Chromosomal Location
ChrIV:240259 to 241197 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YDL124W GO evidence and references
  View Computational GO annotations for YDL124W
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 17 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
14 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Co-purification: 1
  • PCA: 2
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 312
Molecular Weight (Da) 35,560
Isoelectric Point (pI) 6.1
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:240259 to 241197 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..939 240259..241197 2004-02-11 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002282
References cited on this page View Complete Literature Guide for YDL124W
1) Ishihara K, et al.  (2004) Purification and characterization of alpha-keto amide reductase from Saccharomyces cerevisiae. Biosci Biotechnol Biochem 68(11):2306-12
2) Chang Q, et al.  (2007) Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Biochim Biophys Acta 1773(3):321-9
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76