DUN1/YDL101C Summary Help

DUN1 BASIC INFORMATION

Standard Name DUN1 1
Systematic Name YDL101C
Feature Type ORF, Verified
Description Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair (2, 3, 4, 5)
Name Description DNA-damage UNinducible 6
GO Annotations All DUN1 GO evidence and references
    View Computational GO annotations for DUN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulatory Role
Regulatory modules predicted: cellcycle ( 335 )
Mutant Phenotype All DUN1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions DUN1 All interactions details and references
311 total interaction(s) for 180 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-Western: 2
  • Biochemical Activity: 28
  • Protein-peptide: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 5
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 82
  • Phenotypic Suppression: 15
  • Synthetic Growth Defect: 128
  • Synthetic Lethality: 13
  • Synthetic Rescue: 7
Sequence Information
ChrIV:281848 to 280307 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1542 281848..280307 2004-02-11 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002259

DUN1 RESOURCES

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SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for DUN1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DUN1]

1) Elledge, S.  (1993) Personal Communication, Mortimer Map Edition 12
2) Blanchard H, et al.  (2001) Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases. Acta Crystallogr D Biol Crystallogr 57(Pt 3):459-61
3) Zhao X and Rothstein R  (2002) The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Proc Natl Acad Sci U S A 99(6):3746-51
4) Hammet A, et al.  (2002) Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks. J Biol Chem 277(25):22469-74
5) Bashkirov VI, et al.  (2003) Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Mol Cell Biol 23(4):1441-52
6) Zhou Z and Elledge SJ  (1993) DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75(6):1119-27