Standard Name	BUG1 1
Systematic Name	YDL099W
Feature Type	ORF, Verified
Description	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes (1, 2)
Name Description	Binder of USO1 and GRH1 1

Chromosomal Location	ChrIV:283419 to 284444 | ORF Map | GBrowse

	View Computational GO annotations for BUG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IGI, IMP, IPI) protein secretion (IMP)
Cellular Component
Manually curated	cis-Golgi network (IDA, IPI)
High-throughput	cytoplasm (IDA)

Classical genetics
null	KAR2 secretion: abnormal Acb1p secretion: absent
Large-scale survey
null	competitive fitness: decreased haploinsufficient protein transport: abnormal resistance to hydroxyurea: increased resistance to fenpropimorph: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to benzo[a]pyrene: decreased resistance to mycophenolic acid: increased resistance to amitrole: decreased resistance to tunicamycin: increased respiratory growth: absent viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	105 total interaction(s) for 65 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 Biochemical Activity: 2 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Negative Genetic: 41 Phenotypic Enhancement: 20 Phenotypic Suppression: 5 Positive Genetic: 20 Synthetic Growth Defect: 5 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:283419 to 284444 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1026 283419..284444 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002257