RPN6/YDL097C Summary

RPN6 BASIC INFORMATION

Standard Name	RPN6 1
Systematic Name	YDL097C
Alias	NAS4
Feature Type	ORF, Verified
Description	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion (2, 3)
Name Description	Regulatory Particle Non-ATPase 1

GO Annotations	All RPN6 GO evidence and references
	View Computational GO annotations for RPN6
Molecular Function
Manually curated	structural molecule activity (IMP)
Biological Process
Manually curated	proteasome assembly (IMP) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	proteasome regulatory particle, lid subcomplex (IPI) proteasome storage granule (IDA)

Mutant Phenotype	All RPN6 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased

Interactions	RPN6 All interactions details and references
	288 total interaction(s) for 127 unique genes/features.
Physical Interactions	Affinity Capture-MS: 135 Affinity Capture-RNA: 1 Affinity Capture-Western: 8 Co-purification: 18 PCA: 2 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 46 Phenotypic Suppression: 24 Synthetic Growth Defect: 27 Synthetic Lethality: 3 Synthetic Rescue: 21

Sequence Information

ChrIV:286695 to 285391 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1305	286695..285391	2004-02-11	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002255

RPN6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPN6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN6]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	Saito A, et al. (1997) cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome. Gene 203(2):241-50
3)	Santamaria PG, et al. (2003) Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome. J Biol Chem 278(9):6687-95

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