LUC7/YDL087C Summary Help

Standard Name LUC7 1
Systematic Name YDL087C
Alias EXM2 , EPE1
Feature Type ORF, Verified
Description Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia (2, 3, 4)
Name Description Lethal Unless Cap-binding complex is produced 1
Chromosomal Location
ChrIV:300999 to 300214 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All LUC7 GO evidence and references
  View Computational GO annotations for LUC7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
reduction of function
Resources
119 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 96
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 6
  • Positive Genetic: 1
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 261
Molecular Weight (Da) 30,195
Isoelectric Point (pI) 9.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:300999 to 300214 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..786 300999..300214 2004-02-11 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002245
References cited on this page View Complete Literature Guide for LUC7
1) Fortes P, et al.  (1999) Genetic and physical interactions involving the yeast nuclear cap-binding complex. Mol Cell Biol 19(10):6543-53
2) Fortes P, et al.  (1999) Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev 13(18):2425-38
3) Puig O, et al.  (2007) The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human. Nucleic Acids Res 35(17):5874-85
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30