Standard Name	BRE1 1
Systematic Name	YDL074C
Feature Type	ORF, Verified
Description	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control (2, 3, 4)
Name Description	BREfeldin A sensitivity 1

Chromosomal Location	ChrIV:326149 to 324047 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BRE1
Molecular Function
Manually curated	ubiquitin-protein ligase activity (IDA, IMP)
Biological Process
Manually curated	chromatin silencing at telomere (IMP) double-strand break repair via homologous recombination (IGI) histone monoubiquitination (IMP) intra-S DNA damage checkpoint (IMP) meiotic DNA double-strand break formation (IMP) mitotic G1 DNA damage checkpoint (IMP) transcription from RNA polymerase II promoter (IGI, IPI)
Cellular Component
Manually curated	colocalizes_with nuclear chromatin (IDA)

Classical genetics
null	cell cycle progression in S phase: increased rate cell cycle progression through the G1/S phase transition: increased rate tellurium atom accumulation: increased chromosome/plasmid maintenance: abnormal chromosome/plasmid maintenance: decreased chronological lifespan: decreased killer toxin resistance: decreased meiosis: abnormal Nup49p distribution: abnormal Nop1p distribution: abnormal histone H3 modification: absent histone H3 modification: increased Rad53p modification: decreased resistance to calcium dichloride: decreased resistance to Echinocandin B: decreased resistance to phleomycin: decreased resistance to hydroxyurea: decreased resistance to brefeldin A: decreased resistance to tellurite: decreased silencing: absent
Large-scale survey
null	auxotrophy cell size: increased glycogen accumulation: increased glutathione excretion: increased chitin deposition: normal competitive fitness: decreased dessication resistance: decreased freeze-thaw resistance: decreased haploinsufficient heat sensitivity: increased oxidative stress resistance: decreased resistance to L-canavanine: increased resistance to benomyl: increased resistance to dimethyl sulfoxide: decreased resistance to mycophenolic acid: decreased resistance to bleomycin: decreased resistance to methyl methanesulfonate: decreased resistance to quinine: decreased resistance to sodium arsenite: decreased resistance to fluconazole: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to Calcofluor White: decreased resistance to wortmannin: decreased resistance to fenpropimorph: increased resistance to sirolimus: increased resistance to cycloheximide: decreased resistance to paromomycin: decreased resistance to diphenyleneiodonium: decreased resistance to chlorpromazine: decreased resistance to canthardate: decreased resistance to p-chloromercuribenzoic acid: decreased resistance to sorbate: decreased resistance to acrolein: decreased resistance to 1,4-dithiothreitol: decreased resistance to hygromycin B: decreased sporulation: absent sporulation efficiency: decreased stress resistance: decreased telomere length: decreased transposable element transposition: increased vegetative growth: decreased rate viable
overexpression	resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	774 total interaction(s) for 394 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 2 Affinity Capture-Western: 3 Biochemical Activity: 4 Co-localization: 2 PCA: 2 Reconstituted Complex: 5 Two-hybrid: 12
Genetic Interactions	Negative Genetic: 388 Phenotypic Enhancement: 2 Phenotypic Suppression: 3 Positive Genetic: 38 Synthetic Growth Defect: 187 Synthetic Lethality: 105 Synthetic Rescue: 8
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:326149 to 324047 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2103 326149..324047 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002232