RAD59/YDL059C Summary

RAD59 BASIC INFORMATION

Standard Name	RAD59
Systematic Name	YDL059C
Feature Type	ORF, Verified
Description	Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p (1, 2, 3)
Name Description	RADiation sensitive

GO Annotations	All RAD59 GO evidence and references
	View Computational GO annotations for RAD59
Molecular Function
Manually curated	DNA strand annealing activity (IDA) protein binding (IPI)
Biological Process
Manually curated	double-strand break repair via break-induced replication (TAS) double-strand break repair via single-strand annealing (IGI) telomere maintenance via recombination (IMP)
Cellular Component
Manually curated	nucleus (IGI)

Mutant Phenotype	All RAD59 Phenotype details and references
Classical genetics
null	resistance to hydroxyurea: decreased
Large-scale survey
null	mitotic recombination: increased Rad52-YFP distribution: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to cisplatin: decreased resistance to doxorubicin: decreased viable

Interactions	RAD59 All interactions details and references
	119 total interaction(s) for 82 unique genes/features.
Physical Interactions	Affinity Capture-MS: 29 Affinity Capture-Western: 9 Co-localization: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 29 Phenotypic Suppression: 12 Synthetic Growth Defect: 27 Synthetic Lethality: 6 Synthetic Rescue: 2

Sequence Information

ChrIV:344953 to 344237 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-02-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..717	344953..344237	2004-02-11	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002217

RAD59 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RAD59

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RAD59]

1)	Petukhova G, et al. (1999) Single strand DNA binding and annealing activities in the yeast recombination factor Rad59. J Biol Chem 274(48):33839-42
2)	Davis AP and Symington LS (2001) The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing. Genetics 159(2):515-25
3)	Symington LS (2002) Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol Mol Biol Rev 66(4):630-70, table of contents

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