Standard Name	USO1 1
Systematic Name	YDL058W
Alias	INT1
Feature Type	ORF, Verified
Description	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex (1, 2, 3, 4)
Name Description	yUSOu - transport in Japanese 1

Chromosomal Location	ChrIV:345665 to 351037 | ORF Map | GBrowse

	View Computational GO annotations for USO1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IMP) Golgi vesicle docking (IDA) SNARE complex assembly (IMP)
Cellular Component
Manually curated	ER to Golgi transport vesicle membrane (IDA) Golgi membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	cytoskeleton morphology: abnormal endoplasmic reticulum morphology: abnormal nuclear morphology: abnormal invertase secretion: decreased precursor invertase accumulation: increased vacuolar morphology: abnormal
null	inviable
Large-scale survey
null	inviable viable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: normal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	105 total interaction(s) for 84 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 16 Negative Genetic: 50 Positive Genetic: 3 Synthetic Growth Defect: 4 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:345665 to 351037 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..5373 345665..351037 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002216