LHP1/YDL051W Summary Help

LHP1 BASIC INFORMATION

Standard Name LHP1 1
Systematic Name YDL051W
Alias LAH1 , YLA1
Feature Type ORF, Verified
Description RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen (2, 3, 4)
Name Description La-Homologous Protein 1
Gene Product Alias La protein 2
GO Annotations All LHP1 GO evidence and references
    View Computational GO annotations for LHP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All LHP1 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Interactions LHP1 All interactions details and references
89 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-Western: 1
  • Biochemical Activity: 7
  • Reconstituted Complex: 1
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 17
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 6
  • Synthetic Rescue: 3
Sequence Information
ChrIV:363952 to 364779 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..828 363952..364779 2004-02-11 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002209

LHP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for LHP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LHP1]

1) Yoo CJ and Wolin SL  (1994) La proteins from Drosophila melanogaster and Saccharomyces cerevisiae: a yeast homolog of the La autoantigen is dispensable for growth. Mol Cell Biol 14(8):5412-24
2) Yoo CJ and Wolin SL  (1997) The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors. Cell 89(3):393-402
3) Lin-Marq N and Clarkson SG  (1995) A yeast RNA binding protein that resembles the human autoantigen La. J Mol Biol 245(2):81-5
4) Pannone BK, et al.  (1998) A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. EMBO J 17(24):7442-53