GPM2/YDL021W Summary Help

Standard Name GPM2 1
Systematic Name YDL021W
Feature Type ORF, Verified
Description Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog, GPM3, that arose from the whole genome duplication (1, 2 and see Summary Paragraph)
Name Description Glycerate PhosphoMutase 1
Chromosomal Location
ChrIV:413953 to 414888 | ORF Map | GBrowse
Gene Ontology Annotations All GPM2 GO evidence and references
  View Computational GO annotations for GPM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Large-scale survey
9 total interaction(s) for 8 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • PCA: 2

Genetic Interactions
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2

Expression Summary
Length (a.a.) 311
Molecular Weight (Da) 36,073
Isoelectric Point (pI) 6.53
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:413953 to 414888 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..936 413953..414888 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002179

Gpm2p and Gpm3p were originally identified as homologs of Gpm1p, a phosphoglycerate mutase involved in glycolysis. They share 65% identity with each other and 43% identity with Gpm1p. Gpm2p and Gpm3p each contain a conserved 'LLRHGQSELN' motif, a signature sequence of the phosphoglycerate mutase family. In addition, residues of Gpm1p shown to be involved in catalysis (His8, Arg59, His181) are conserved in Gpm2p and Gpm3p. Despite this homology, neither gene complements a gpm1 deletion in strain VW1A when overexpressed on high copy number plasmids under the control of their weak endogenous promoters. However, GPM2 and GPM3 partially restore activity and growth to a gpm1 deletion mutant when overexpressed from the yeast PFK1 promoter. By following the intermediary metabolites preceding and succeeding the GPM reaction, it has been demonstrated that neither the gpm2 nor the gpm3 deletion mutation affects glycolysis, nor does it confer any obvious phenotype. It has been proposed that GPM2 and GPM3 may be non-functional homologues of GPM1 that were generated by a gene duplication event and then diverged from the parent copy by mutation (3).

Last updated: 2003-09-11 Contact SGD

References cited on this page View Complete Literature Guide for GPM2
1) Heinisch JJ, et al.  (1998) Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase. Yeast 14(3):203-13
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Rodicio R and Heinisch J  (1987) Isolation of the yeast phosphoglyceromutase gene and construction of deletion mutants. Mol Gen Genet 206(1):133-40