SLX5/YDL013W Summary Help

SLX5 BASIC INFORMATION

Standard Name SLX5 1
Systematic Name YDL013W
Alias HEX3 2 , ULS2 3
Feature Type ORF, Verified
Description Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers (1, 4, 5, 6, 7)
Name Description Synthetic Lethal of unknown [X] function 1
GO Annotations All SLX5 GO evidence and references
    View Computational GO annotations for SLX5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SLX5 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
overexpression
Interactions SLX5 All interactions details and references
425 total interaction(s) for 272 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 13
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 29
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 125
  • Phenotypic Suppression: 63
  • Synthetic Growth Defect: 116
  • Synthetic Lethality: 52
  • Synthetic Rescue: 6
Sequence Information
ChrIV:429065 to 430924 | ORF Map | GBrowse
Gbrowse
Genetic position: -1.69 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1860 429065..430924 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002171

SLX5 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SLX5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SLX5]

1) Mullen JR, et al.  (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157(1):103-18
2) Sternglanz, R.  (1993) Personal Communication, Mortimer Map Edition 12
3) Uzunova K, et al.  (2007) Ubiquitin-dependent Proteolytic Control of SUMO Conjugates. J Biol Chem 282(47):34167-75
4) Wang Z, et al.  (2006) Genetic Analysis Connects SLX5 and SLX8 to the SUMO Pathway in Saccharomyces cerevisiae. Genetics 172(3):1499-509
5) Xie Y, et al.  (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84
6) Ii T, et al.  (2007) The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity. Cell Cycle 6(22):2800-9
7) Cook CE, et al.  (2009) The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks. Cell Cycle 8(7):1080-9