Standard Name	GRX6 1, 2 (see Nomenclature conflict Note)
Systematic Name	YDL010W
Feature Type	ORF, Verified
Description	Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6)
Name Description	GlutaRedoXin 2

Chromosomal Location	ChrIV:432330 to 433025 | ORF Map | GBrowse

	View Computational GO annotations for GRX6
Molecular Function
Manually curated	2 iron, 2 sulfur cluster binding (IDA) glutathione-disulfide reductase activity (IDA, IMP) iron ion binding (IDA) protein homodimerization activity (IDA)
Biological Process
Manually curated	cellular response to oxidative stress (IEP, IGI, IMP)
Cellular Component
Manually curated	cis-Golgi network (IDA) endoplasmic reticulum membrane (IDA) Golgi apparatus (IDA) Golgi lumen (IDA) integral to membrane (IDA)
High-throughput	fungal-type vacuole (IDA)

Classical genetics
null	heat sensitivity: increased oxidative stress resistance: decreased resistance to tunicamycin: increased
Large-scale survey
null	auxotrophy competitive fitness: decreased resistance to benzo[a]pyrene: increased resistance to benzo[a]pyrene: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	14 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Co-crystal Structure: 1 Co-fractionation: 2 Reconstituted Complex: 2
Genetic Interactions	Negative Genetic: 1 Synthetic Growth Defect: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:432330 to 433025 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..696 432330..433025 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002168