PTC1/YDL006W Summary Help

Standard Name PTC1 1
Systematic Name YDL006W
Alias CWH47 , KCS2 , TPD1
Feature Type ORF, Verified
Description Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation (2, 3, 4, 5, 6, 7)
Name Description Phosphatase type Two C 1
Chromosomal Location
ChrIV:439909 to 440754 | ORF Map | GBrowse
Gene Ontology Annotations All PTC1 GO evidence and references
  View Computational GO annotations for PTC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
Large-scale survey
628 total interaction(s) for 410 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Biochemical Activity: 12
  • PCA: 18
  • Reconstituted Complex: 6
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 8
  • Negative Genetic: 403
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 9
  • Positive Genetic: 80
  • Synthetic Growth Defect: 39
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 17
  • Synthetic Rescue: 6

Expression Summary
Length (a.a.) 281
Molecular Weight (Da) 31,549
Isoelectric Point (pI) 4.72
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:439909 to 440754 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..846 439909..440754 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002164
References cited on this page View Complete Literature Guide for PTC1
1) Maeda T, et al.  (1993) Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Mol Cell Biol 13(9):5408-17
2) Robinson MK, et al.  (1994) TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation. Mol Cell Biol 14(6):3634-45
3) van Zyl WH, et al.  (1989) A general screen for mutant of Saccharomyces cerevisiae deficient in tRNA biosynthesis. Genetics 123(1):55-68
4) Maeda T, et al.  (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369(6477):242-5
5) Roeder AD, et al.  (1998) Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase PTC1. Mol Biol Cell 9(4):917-30
6) Warmka J, et al.  (2001) Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Mol Cell Biol 21(1):51-60
7) Malleshaiah MK, et al.  (2010) The scaffold protein Ste5 directly controls a switch-like mating decision in yeast. Nature 465(7294):101-5