Standard Name	NHP10
Systematic Name	YDL002C
Alias	HMO2 1
Feature Type	ORF, Verified
Description	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair (1, 2, 3, 4, 5)
Name Description	Non-Histone Protein

Chromosomal Location	ChrIV:447578 to 446967 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NHP10
Molecular Function
Manually curated	DNA end binding (IDA) loop DNA binding (IDA)
Biological Process
Manually curated	double-strand break repair (IGI, IMP) nucleosome mobilization (IDA)
Cellular Component
Manually curated	Ino80 complex (IDA)
High-throughput	nucleus (IDA)

Binding motifs	RCCGGGGA 6 [Search intergenic regions for RCCGGGGA]
Resources	ScerTF | YeTFaSCo

Classical genetics
null	chromosome/plasmid maintenance: abnormal telomere length: increased
overexpression	nuclear morphology: abnormal
Large-scale survey
null	auxotrophy competitive fitness: decreased endocytosis: decreased haploinsufficient resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to tunicamycin: decreased resistance to cycloheximide: decreased toxin resistance: decreased vegetative growth: decreased rate viable
overexpression	cell cycle progression: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	445 total interaction(s) for 319 unique genes/features.
Physical Interactions	Affinity Capture-MS: 76 Affinity Capture-RNA: 3 Affinity Capture-Western: 2 Biochemical Activity: 8 PCA: 1 Two-hybrid: 11
Genetic Interactions	Dosage Growth Defect: 2 Negative Genetic: 277 Phenotypic Enhancement: 3 Phenotypic Suppression: 1 Positive Genetic: 28 Synthetic Growth Defect: 27 Synthetic Lethality: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:447578 to 446967 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..612 447578..446967 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002160