NHP10/YDL002C Summary

NHP10 BASIC INFORMATION

Standard Name	NHP10
Systematic Name	YDL002C
Alias	HMO2 1
Feature Type	ORF, Verified
Description	Protein related to mammalian high mobility group proteins; binds preferentially to DNA ends and is able to protect them from exonuclease cleavage; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex (1, 2, 3)
Name Description	Non-Histone Protein

GO Annotations	All NHP10 GO evidence and references
	View Computational GO annotations for NHP10
Molecular Function
Manually curated	DNA end binding (IDA) loop DNA binding (IDA)
Biological Process
Manually curated	chromatin remodeling (IPI)
Cellular Component
Manually curated	Ino80 complex (IPI)
High-throughput	nucleus (IDA)

Mutant Phenotype	All NHP10 Phenotype details and references
Classical genetics
null	chromosome/plasmid maintenance: abnormal telomere length: increased
overexpression	nuclear morphology: abnormal
Large-scale survey
null	resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased viable
overexpression	cell cycle progression: abnormal

Interactions	NHP10 All interactions details and references
	167 total interaction(s) for 102 unique genes/features.
Physical Interactions	Affinity Capture-MS: 72 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 8 PCA: 1 Two-hybrid: 6
Genetic Interactions	Phenotypic Enhancement: 47 Phenotypic Suppression: 10 Synthetic Growth Defect: 13 Synthetic Lethality: 6 Synthetic Rescue: 1

Sequence Information

ChrIV:447576 to 446965 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..612	447576..446965	2008-06-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002160

NHP10 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for NHP10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NHP10]

1)	Lu J, et al. (1996) Characterization of a high mobility group 1/2 homolog in yeast. J Biol Chem 271(52):33678-85
2)	Shen X, et al. (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
3)	Ray S and Grove A (2009) The yeast high mobility group protein HMO2, a subunit of the chromatin-remodeling complex INO80, binds DNA ends. Nucleic Acids Res 37(19):6389-99

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