PTC6/YCR079W Summary Help

PTC6 BASIC INFORMATION

Standard Name PTC6 1
Systematic Name YCR079W
Alias AUP1 2 , PPP2 3
Feature Type ORF, Verified
Description Mitochondrial protein phosphatase of type 2C with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase (1, 2, 3, 4, 5)
Name Description Phosphatase Two C 1
GO Annotations All PTC6 GO evidence and references
    View Computational GO annotations for PTC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All PTC6 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
Interactions PTC6 All interactions details and references
32 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 18
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 2
Genetic Interactions
  • Dosage Growth Defect: 1
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
Sequence Information
ChrIII:252842 to 254170 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-12 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1329 252842..254170 2006-01-12 2000-09-13
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002133

PTC6 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PTC6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PTC6]

1) Ruan H, et al.  (2007) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):209-15
2) Tal R, et al.  (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 282(8):5617-24
3) Gey U, et al.  (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem 283(15):9759-67
4) Tomaska L  (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64
5) Sakumoto N, et al.  (2002) A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast 19(7):587-99