PMP2/YEL017C-A Summary Help

Standard Name PMP2 1
Systematic Name YEL017C-A
Feature Type ORF, Verified
Description Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Plasma Membrane Proteolipid 1
Chromosomal Location
ChrV:122929 to 122798 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PMP2 GO evidence and references
  View Computational GO annotations for PMP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 172 genes
Resources
Large-scale survey
null
Resources
47 total interaction(s) for 44 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 8
  • PCA: 26
  • Protein-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 6
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 43
Molecular Weight (Da) 4,848
Isoelectric Point (pI) 12.09
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:122929 to 122798 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..132 122929..122798 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002103
References cited on this page View Complete Literature Guide for PMP2
1) Navarre C, et al.  (1994) Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. J Biol Chem 269(33):21262-8
2) Navarre C and Goffeau A  (1998) The plasma membrane H(+)-ATPase of Saccharomyces cerevisiae is regulated by two small 38-residue isoproteolipids. Folia Microbiol (Praha) 43(2):206-8
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76