RPN12/YFR052W Summary Help

RPN12 BASIC INFORMATION

Standard Name RPN12 1
Systematic Name YFR052W
Alias NIN1
Feature Type ORF, Verified
Description Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p (2, 3)
Name Description Regulatory Particle Non-ATPase 1
GO Annotations All RPN12 GO evidence and references
    View Computational GO annotations for RPN12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All RPN12 Phenotype details and references
Large-scale survey
null
Interactions RPN12 All interactions details and references
214 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 123
  • Affinity Capture-Western: 23
  • Co-fractionation: 1
  • Co-purification: 5
  • Reconstituted Complex: 1
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 3
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 8
  • Synthetic Rescue: 16
Sequence Information
ChrVI:252492 to 253316 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2003-09-26 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..825 252492..253316 2003-09-26 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001948

RPN12 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for RPN12

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN12]

1) Finley D, et al.  (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2) Takeuchi J and Toh-e A  (1999) Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic lethality. Mol Gen Genet 262(1):145-53
3) Tone Y, et al.  (2000) Nob1p, a new essential protein, associates with the 26S proteasome of growing saccharomyces cerevisiae cells. Gene 243(1-2):37-45