RSC8/YFR037C Summary

RSC8 BASIC INFORMATION

Standard Name	RSC8
Systematic Name	YFR037C
Alias	SWH3
Feature Type	ORF, Verified
Description	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters (1, 2, 3, 4)
Name Description	Remodel the Structure of Chromatin 2

GO Annotations	All RSC8 GO evidence and references
	View Computational GO annotations for RSC8
Molecular Function
Manually curated	contributes_to DNA-dependent ATPase activity (IDA)
Biological Process
Manually curated	ATP-dependent chromatin remodeling (IDA) double-strand break repair via nonhomologous end joining (IDA, IMP) G1/S transition of mitotic cell cycle (IMP) nucleosome disassembly (IDA) regulation of transcription (IMP) RNA elongation from RNA polymerase II promoter (IDA)
Cellular Component
Manually curated	RSC complex (IDA)
High-throughput	nucleus (IDA)

Mutant Phenotype	All RSC8 Phenotype details and references
Classical genetics
repressible	cell cycle progression in G1 phase: arrested cell cycle progression through the G2/M phase transition: arrested
Large-scale survey
null	inviable

Interactions	RSC8 All interactions details and references
	231 total interaction(s) for 124 unique genes/features.
Physical Interactions	Affinity Capture-MS: 135 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 5 Phenotypic Enhancement: 54 Phenotypic Suppression: 17 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrVI:229173 to 227500 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2003-09-26 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1674	229173..227500	2003-09-26	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001933

RSC8 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for RSC8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RSC8]

1)	Treich I and Carlson M (1997) Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae. Mol Cell Biol 17(4):1768-75
2)	Cairns BR, et al. (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
3)	Lorch Y, et al. (1998) Activated RSC-nucleosome complex and persistently altered form of the nucleosome. Cell 94(1):29-34
4)	Neely KE and Workman JL (2002) The complexity of chromatin remodeling and its links to cancer. Biochim Biophys Acta 1603(1):19-29

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