CDC14/YFR028C Summary Help

CDC14 BASIC INFORMATION

Standard Name CDC14 1
Systematic Name YFR028C
Alias OAF3
Feature Type ORF, Verified
Description Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit (2, 3, 4, 5)
Name Description Cell Division Cycle 6
GO Annotations All CDC14 GO evidence and references
    View Computational GO annotations for CDC14
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulatory Role
Regulatory modules predicted: stressResponse ( 601 , 403 )
Mutant Phenotype All CDC14 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
repressible
Interactions CDC14 All interactions details and references
164 total interaction(s) for 78 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 21
  • Biochemical Activity: 14
  • Co-localization: 6
  • Reconstituted Complex: 8
  • Two-hybrid: 17
Genetic Interactions
  • Dosage Lethality: 4
  • Dosage Rescue: 17
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 17
  • Synthetic Rescue: 12
Sequence Information
ChrVI:210056 to 208401 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 36 cM
Last Update Coordinates: 2003-09-26 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1656 210056..208401 2003-09-26 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001924

CDC14 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for CDC14

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CDC14]

1) Culotti J and Hartwell LH  (1971) Genetic control of the cell division cycle in yeast. 3. Seven genes controlling nuclear division. Exp Cell Res 67(2):389-401
2) Wan J, et al.  (1992) CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle. J Biol Chem 267(16):11274-80
3) Visintin R, et al.  (1998) The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell 2(6):709-18
4) Taylor GS, et al.  (1997) The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. J Biol Chem 272(38):24054-63
5) Saunders WS  (2002) The FEAR factor. Mol Cell 9(2):207-9
6) Hartwell LH, et al.  (1970) Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci U S A 66(2):352-9